WDR4 Antibody

Product Specifications

Background

This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This gene is excluded as a candidate for a form of nonsyndromic deafness (DFNB10), but is still a candidate for other disorders mapped to 21q22.3 as well as for the development of Down syndrome phenotypes. Two transcript variants encoding the same protein have been found for this gene.

NCBI Gene ID

10785

Swiss Prot

P57081

Accession Number

P57081

Host

Rabbit

Reactivity

Human

Immunogen

This WDR4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 146-173 amino acids from the Central region of human WDR4.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Other

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Homology

Predicted species reactivity based on immunogen sequence: Bovine, Mouse

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

45 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

WDR4

NCBI Official Name

TRNA (guanine-N (7) -) -methyltransferase non-catalytic subunit WDR4 {ECO:0000255|HAMAP-Rule:MF_03056}

NCBI Organism

Homo sapiens

Background Reference 01

Sugiyama, N., et al. Mol. Cell Proteomics 6 (6) :1103-1109 (2007)

Background Reference 02

Olsen, J.V., et al. Cell 127 (3) :635-648 (2006)

Background Reference 03

Hu, Y.H., et al. BMC Genomics 7, 155 (2006) :

Background Reference 04

Cartlidge, R.A., et al. EMBO J. 24 (9) :1696-1705 (2005)

Other Product Names

TRNA (guanine-N (7) -) -methyltransferase non-catalytic subunit WDR4 {ECO:0000255|HAMAP-Rule:MF_03056}, WD repeat-containing protein 4 {ECO:0000255|HAMAP-Rule:MF_03056}, WDR4 {ECO:0000255|HAMAP-Rule:MF_03056}