PPIE Antibody

Product Specifications

Background

The protein encoded by this gene is a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family. PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of proteins. This protein contains a highly conserved cyclophilin (CYP) domain as well as an RNA-binding domain. It was shown to possess PPIase and protein folding activities, and it also exhibits RNA-binding activity. Alternative splicing results in multiple transcript variants. A related pseudogene, which is also located on chromosome 1, has been identified.

NCBI Gene ID

10450

Swiss Prot

Q9UNP9

Accession Number

Q9UNP9

Host

Rabbit

Reactivity

Human

Immunogen

This PPIE antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 22-49 amino acids from the N-terminal region of human PPIE.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Signal Transduction

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Homology

Predicted species reactivity based on immunogen sequence: Bovine, Mouse

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

33 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

PPIE

NCBI Official Name

Peptidyl-prolyl cis-trans isomerase E

NCBI Organism

Homo sapiens

Background Reference 01

Park, S., et al. Biochemistry 49 (31) :6576-6586 (2010)

Background Reference 02

Hom, R.A., et al. J. Mol. Biol. 400 (2) :145-154 (2010)

Background Reference 03

Wang, Z., et al. Cell 141 (7) :1183-1194 (2010)

Background Reference 04

Naukkarinen, J., et al. PLoS Genet. (6), E1000976 (2010) :

Other Product Names

Peptidyl-prolyl cis-trans isomerase E, PPIase E, Cyclophilin E, Cyclophilin-33, Rotamase E, PPIE, CYP33

Tested Applications

Protein ID

13124097

Physical Properties

Liquid

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