TGM3 Antibody

Product Specifications

Background

Transglutaminases are enzymes that catalyze the crosslinking of proteins by epsilon-gamma glutamyl lysine isopeptide bonds. While the primary structure of transglutaminases is not conserved, they all have the same amino acid sequence at their active sites and their activity is calcium-dependent. The protein encoded by this gene consists of two polypeptide chains activated from a single precursor protein by proteolysis. The encoded protein is involved the later stages of cell envelope formation in the epidermis and hair follicle.

NCBI Gene ID

7053

Swiss Prot

Q08188

Accession Number

Q08188

Host

Rabbit

Reactivity

Human

Immunogen

This TGM3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 539-567 amino acids from the C-terminal region of human TGM3.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Obesity, Signal Transduction

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

77 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

TGM3

NCBI Official Name

Protein-glutamine gamma-glutamyltransferase E

NCBI Organism

Homo sapiens

Background Reference 01

Yamane, A., et al. FEBS J. 277 (17) :3564-3574 (2010)

Background Reference 02

Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :

Background Reference 03

Negishi, A., et al. Cancer Sci. 100 (9) :1605-1611 (2009)

Background Reference 04

Fujimoto, A., et al. J. Hum. Genet. 54 (8) :461-465 (2009)

Other Product Names

Protein-glutamine gamma-glutamyltransferase E, Transglutaminase E, TG (E), TGE, TGase E, Transglutaminase-3, TGase-3, Protein-glutamine gamma-glutamyltransferase E 50 kDa catalytic chain, Protein-glutamine gamma-glutamyltransferase E 27 kDa non-catalytic chain, TGM3