ITK Antibody
Product Specifications
Background
This gene encodes an intracellular tyrosine kinase expressed in T-cells. The protein contains both SH2 and SH3 domains which are often found in intracellular kinases. It is thought to play a role in T-cell proliferation and differentiation. [provided by RefSeq].
NCBI Gene ID
3702
Swiss Prot
Q08881
Accession Number
Q08881
Host
Rabbit
Reactivity
Human
Immunogen
This ITK antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 25-54 amino acids from the N-terminal region of human ITK.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Mouse
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
72 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
ITK
NCBI Official Name
Tyrosine-protein kinase ITK/TSK
NCBI Organism
Homo sapiens
Background Reference 01
Grasis, J.A., et al. Mol. Cell. Biol. 30 (14) :3596-3609 (2010)
Background Reference 02
Pechloff, K., et al. J. Exp. Med. 207 (5) :1031-1044 (2010)
Background Reference 03
Qi, Q., et al. J. Biol. Chem. 284 (43) :29882-29892 (2009)
Background Reference 04
Kogina, K., et al. Mol. Cells 28 (2) :125-130 (2009)
Other Product Names
Tyrosine-protein kinase ITK/TSK, Interleukin-2-inducible T-cell kinase, IL-2-inducible T-cell kinase, Kinase EMT, T-cell-specific kinase, Tyrosine-protein kinase Lyk, ITK, EMT, LYK
Tested Applications
WB
Protein ID
585361
Physical Properties
Liquid
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