ITK Antibody

Product Specifications

Background

This gene encodes an intracellular tyrosine kinase expressed in T-cells. The protein contains both SH2 and SH3 domains which are often found in intracellular kinases. It is thought to play a role in T-cell proliferation and differentiation. [provided by RefSeq].

NCBI Gene ID

3702

Swiss Prot

Q08881

Accession Number

Q08881

Host

Rabbit

Reactivity

Human

Immunogen

This ITK antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 25-54 amino acids from the N-terminal region of human ITK.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Signal Transduction

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Homology

Predicted species reactivity based on immunogen sequence: Mouse

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

72 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

ITK

NCBI Official Name

Tyrosine-protein kinase ITK/TSK

NCBI Organism

Homo sapiens

Background Reference 01

Grasis, J.A., et al. Mol. Cell. Biol. 30 (14) :3596-3609 (2010)

Background Reference 02

Pechloff, K., et al. J. Exp. Med. 207 (5) :1031-1044 (2010)

Background Reference 03

Qi, Q., et al. J. Biol. Chem. 284 (43) :29882-29892 (2009)

Background Reference 04

Kogina, K., et al. Mol. Cells 28 (2) :125-130 (2009)

Other Product Names

Tyrosine-protein kinase ITK/TSK, Interleukin-2-inducible T-cell kinase, IL-2-inducible T-cell kinase, Kinase EMT, T-cell-specific kinase, Tyrosine-protein kinase Lyk, ITK, EMT, LYK