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APPL2 Antibody

Product Specifications

Background

Required for the regulation of cell proliferation in response to extracellular signals mediated by an early endosomal compartment. Links Rab5 to nuclear signal transduction.

NCBI Gene ID

55198

Swiss Prot

Q8NEU8

Accession Number

Q8NEU8

Host

Rabbit

Reactivity

Human

Immunogen

This APPL2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 124-152 amino acids from the N-terminal region of human APPL2.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Signal Transduction

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Homology

Predicted species reactivity based on immunogen sequence: Mouse

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

74 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

APPL2

NCBI Official Name

DCC-interacting protein 13-beta

NCBI Organism

Homo sapiens

Background Reference 01

Chial, H.J., et al. PLoS ONE (8), E12471 (2010) :

Background Reference 02

Rashid, S., et al. J. Biol. Chem. 284 (27) :18115-18128 (2009)

Background Reference 03

Chial, H.J., et al. Traffic 9 (2) :215-229 (2008)

Background Reference 04

Nechamen, C.A., et al. Mol. Cell. Endocrinol. 260-262, 93-99 (2007) :

Other Product Names

DCC-interacting protein 13-beta, Dip13-beta, Adapter protein containing PH domain, PTB domain and leucine zipper motif 2, APPL2, DIP13B

Tested Applications

WB

Protein ID

160419148

Physical Properties

Liquid

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