PPFIBP1 Antibody

Product Specifications

Background

The protein encoded by this gene is a member of the LAR protein-tyrosine phosphatase-interacting protein (liprin) family. Liprins interact with members of LAR family of transmembrane protein tyrosine phosphatases, which are known to be important for axon guidance and mammary gland development. It has been proposed that liprins are multivalent proteins that form complex structures and act as scaffolds for the recruitment and anchoring of LAR family of tyrosine phosphatases. This protein was found to interact with S100A4, a calcium-binding protein related to tumor invasiveness and metastasis. In vitro experiment demonstrated that the interaction inhibited the phosphorylation of this protein by protein kinase C and protein kinase CK2. Alternatively spliced transcript variants encoding distinct isoforms have been reported.

NCBI Gene ID

8496

Swiss Prot

Q86W92

Accession Number

Q86W92

Host

Rabbit

Reactivity

Human

Immunogen

This PPFIBP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 588-617 amino acids from the Central region of human PPFIBP1.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Signal Transduction

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Homology

Predicted species reactivity based on immunogen sequence: Mouse

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

114 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:2000

Symbol

PPFIBP1

NCBI Official Name

Liprin-beta-1

NCBI Organism

Homo sapiens

Background Reference 01

Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :

Background Reference 02

Norrmen, C., et al. Blood 115 (4) :906-909 (2010)

Background Reference 03

Ewing, R.M., et al. Mol. Syst. Biol. 3, 89 (2007) :

Background Reference 04

Olsen, J.V., et al. Cell 127 (3) :635-648 (2006)

Other Product Names

Liprin-beta-1, Protein tyrosine phosphatase receptor type f polypeptide-interacting protein-binding protein 1, PTPRF-interacting protein-binding protein 1, hSGT2, PPFIBP1, KIAA1230