HECTD3 Antibody
Product Specifications
Background
E3 ubiquitin ligases accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates ubiquitination of TRIOBP and its subsequent proteasomal degradation, thus faciliting cell cycle progression by regulating the turn-over of TRIOBP. Mediates also ubiquitination of STX8 (By similarity) .
NCBI Gene ID
79654
Swiss Prot
Q5T447
Accession Number
Q5T447
Host
Rabbit
Reactivity
Human
Immunogen
This HECTD3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 740-769 amino acids from the C-terminal region of human HECTD3.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cell Cycle
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
97 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
HECTD3
NCBI Official Name
E3 ubiquitin-protein ligase HECTD3
NCBI Organism
Homo sapiens
Background Reference 01
Yu, J., et al. Biochem. Biophys. Res. Commun. 367 (4) :805-812 (2008)
Background Reference 02
Gevaert, K., et al. Nat. Biotechnol. 21 (5) :566-569 (2003)
Other Product Names
E3 ubiquitin-protein ligase HECTD3, 632-, HECT domain-containing protein 3, HECTD3
Tested Applications
WB
Protein ID
74744877
Physical Properties
Liquid
Curated Selection
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