LETM1 Antibody

Product Specifications

Background

This gene encodes a protein that is localized to the inner mitochondrial membrane. The protein functions to maintain the mitochondrial tubular shapes and is required for normal mitochondrial morphology and cellular viability. Mutations in this gene cause Wolf-Hirschhorn syndrome, a complex malformation syndrome caused by the deletion of parts of the distal short arm of chromosome 4. Related pseudogenes have been identified on chromosomes 8, 15 and 19.

NCBI Gene ID

3954

Swiss Prot

O95202

Accession Number

O95202

Host

Rabbit

Reactivity

Human

Immunogen

This LETM1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 577-607 amino acids from the C-terminal region of human LETM1.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Obesity

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

83 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

LETM1

NCBI Official Name

LETM1 and EF-hand domain-containing protein 1, mitochondrial

NCBI Organism

Homo sapiens

Background Reference 01

Jiang, D., et al. Science 326 (5949) :144-147 (2009)

Background Reference 02

Piao, L., et al. Cell. Signal. 21 (5) :767-777 (2009)

Background Reference 03

Piao, L., et al. Cancer Res. 69 (8) :3397-3404 (2009)

Background Reference 04

Tamai, S., et al. J. Cell. Sci. 121 (PT 15), 2588-2600 (2008) :

Other Product Names

LETM1 and EF-hand domain-containing protein 1, mitochondrial, Leucine zipper-EF-hand-containing transmembrane protein 1, LETM1

Tested Applications

Physical Properties

Liquid

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