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Mouse Sik2 Antibody

Product Specifications

Background

Phosphorylates 'Ser-789' of IRS1 in insulin-stimulated adipocytes, potentially modulating the efficiency of insulin signal transduction. Inhibits CREB activity by phosphorylating and repressing TORCs, the CREB-specific coactivators.

NCBI Gene ID

235344

Swiss Prot

Q8CFH6

Accession Number

Q8CFH6

Host

Rabbit

Reactivity

Mouse

Immunogen

This Mouse Sik2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 606-633 amino acids from the Central region of mouse Sik2.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Signal Transduction

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

104 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

Sik2

NCBI Official Name

Serine/threonine-protein kinase SIK2

NCBI Organism

Mus musculus

Background Reference 01

Trivedi, C.M., et al. Dev. Cell 19 (3) :450-459 (2010)

Background Reference 02

Muraoka, M., et al. Am. J. Physiol. Endocrinol. Metab. 296 (6), E1430-E1439 (2009) :

Background Reference 03

Du, J., et al. Obesity (Silver Spring) 16 (3) :531-538 (2008)

Background Reference 04

Katoh, Y., et al. FEBS J. 273 (12) :2730-2748 (2006)

Other Product Names

Serine/threonine-protein kinase SIK2, Salt-inducible kinase 2, SIK-2, Serine/threonine-protein kinase SNF1-like kinase 2, Sik2, Snf1lk2

Tested Applications

WB

Physical Properties

Liquid

Frequently Asked Questions

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