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Mouse Rnasel Antibody

Product Specifications

Background

Endoribonuclease that functions in the interferon (IFN) antiviral response. In INF treated and virus infected cells, RNASEL probably mediates its antiviral effects through a combination of direct cleavage of single-stranded viral RNAs, inhibition of protein synthesis through the degradation of rRNA, induction of apoptosis, and induction of other antiviral genes. RNASEL mediated apoptosis is the result of a JNK-dependent stress-response pathway leading to cytochrome c release from mitochondria and caspase-dependent apoptosis. Therefore, activation of RNASEL could lead to elimination of virus infected cells under some circumstances. Might play a central role in the regulation of mRNA turnover (By similarity) .

NCBI Gene ID

24014

Swiss Prot

Q05921

Accession Number

Q05921

Host

Rabbit

Reactivity

Mouse

Immunogen

This Mouse Rnasel antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 140-167 amino acids from the N-terminal region of mouse Rnasel.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Immunology

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Product Datasheet

https://www.prosci-inc.com/?datasheet_sku=59-203

Calculated Molecular Weight

83 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

Rnasel

NCBI Official Name

2-5A-dependent ribonuclease

NCBI Organism

Mus musculus

Background Reference 01

Ireland, D.D., et al. PLoS Pathog. (10), E1000602 (2009) :

Background Reference 02

Andersen, J.B., et al. RNA Biol 6 (3) :305-315 (2009)

Background Reference 03

Salehzada, T., et al. PLoS ONE (10), E7563 (2009) :

Background Reference 04

Li, X.L., et al. Proc. Natl. Acad. Sci. U.S.A. 105 (52) :20816-20821 (2008)

Other Product Names

2-5A-dependent ribonuclease, 2-5A-dependent RNase, 3126-, Ribonuclease 4, Ribonuclease L, RNase L, Rnasel, Rns4

Tested Applications

WB

Physical Properties

Liquid

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