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CLCNKA Antibody

Product Specifications

Background

This gene is a member of the CLC family of voltage-gated chloride channels. The encoded protein is predicted to have 12 transmembrane domains, and requires a beta subunit called barttin to form a functional channel. It is thought to function in salt reabsorption in the kidney and potassium recycling in the inner ear. The gene is highly similar to CLCNKB, which is located 10 kb downstream from this gene. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq].

NCBI Gene ID

1187

Swiss Prot

P51800

Accession Number

P51800

Host

Rabbit

Reactivity

Human

Immunogen

This CLCNKA antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 20-47 amino acids from the N-terminal region of human CLCNKA.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Neuroscience, Signal Transduction

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

75 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

CLCNKA

NCBI Official Name

Chloride channel protein ClC-Ka

NCBI Organism

Homo sapiens

Background Reference 01

Bailey, S.D., et al. Diabetes Care (2010) In press :

Background Reference 02

Talmud, P.J., et al. Am. J. Hum. Genet. 85 (5) :628-642 (2009)

Background Reference 03

Kramer, B.K., et al. Nat Clin Pract Nephrol 4 (1) :38-46 (2008)

Background Reference 04

Martinez, G.Q., et al. PLoS ONE (7), E2746 (2008) :

Other Product Names

Chloride channel protein ClC-Ka, Chloride channel Ka, ClC-K1, CLCNKA

Tested Applications

WB

Protein ID

1705857

Physical Properties

Liquid

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