PPFIA1 Antibody

Product Specifications

Background

The protein encoded by this gene is a member of the LAR protein-tyrosine phosphatase-interacting protein (liprin) family. Liprins interact with members of LAR family of transmembrane protein tyrosine phosphatases, which are known to be important for axon guidance and mammary gland development. This protein binds to the intracellular membrane-distal phosphatase domain of tyrosine phosphatase LAR, and appears to localize LAR to cell focal adhesions. This interaction may regulate the disassembly of focal adhesion and thus help orchestrate cell-matrix interactions. Alternatively spliced transcript variants encoding distinct isoforms have been described.

NCBI Gene ID

8500

Swiss Prot

Q13136

Accession Number

Q13136

Host

Rabbit

Reactivity

Human

Immunogen

This PPFIA1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 52-80 amino acids from the N-terminal region of human PPFIA1.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Neuroscience, Signal Transduction

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

136 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

PPFIA1

NCBI Official Name

Liprin-alpha-1

NCBI Organism

Homo sapiens

Background Reference 01

Asperti, C., et al. Exp. Cell Res. 316 (6) :915-926 (2010)

Background Reference 02

Dancau, A.M., et al. Genes Chromosomes Cancer 49 (1) :1-8 (2010)

Background Reference 03

Asperti, C., et al. J. Cell. Sci. 122 (PT 18), 3225-3232 (2009) :

Background Reference 04

Venkatesan, K., et al. Nat. Methods 6 (1) :83-90 (2009)

Other Product Names

Liprin-alpha-1, LAR-interacting protein 1, LIP-1, Protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-1, PTPRF-interacting protein alpha-1, PPFIA1, LIP1