SOSTDC1 Antibody

Product Specifications

Background

This gene is a member of the sclerostin family and encodes an N-glycosylated, secreted protein with a C-terminal cystine knot-like domain. This protein functions as a bone morphogenetic protein (BMP) antagonist. Specifically, it directly associates with BMPs, prohibiting them from binding their receptors, thereby regulating BMP signaling during cellular proliferation, differentiation, and programmed cell death.

NCBI Gene ID

25928

Swiss Prot

Q6X4U4

Accession Number

Q6X4U4

Host

Rabbit

Reactivity

Human, Mouse

Immunogen

This SOSTDC1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 169-196 amino acids from the C-terminal region of human SOSTDC1.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Signal Transduction

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

23 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

SOSTDC1

NCBI Official Name

Sclerostin domain-containing protein 1

NCBI Organism

Homo sapiens

Background Reference 01

Barber, M.J., et al. PLoS ONE (3), E9763 (2010) :

Background Reference 02

Ohshima, J., et al. Genes Chromosomes Cancer 48 (12) :1037-1050 (2009)

Background Reference 03

Blish, K.R., et al. Mol. Biol. Cell 19 (2) :457-464 (2008)

Background Reference 04

Lamesch, P., et al. Genomics 89 (3) :307-315 (2007)

Other Product Names

Sclerostin domain-containing protein 1, Ectodermal BMP inhibitor, Ectodin, Uterine sensitization-associated gene 1 protein, USAG-1, SOSTDC1, USAG1

Tested Applications

Protein ID

62287504

Physical Properties

Liquid

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