SOST Antibody

Product Specifications

Background

Sclerostin is a secreted glycoprotein with a C-terminal cysteine knot-like (CTCK) domain and sequence similarity to the DAN (differential screening-selected gene aberrative in neuroblastoma) family of bone morphogenetic protein (BMP) antagonists. Loss-of-function mutations in this gene are associated with an autosomal-recessive disorder, sclerosteosis, which causes progressive bone overgrowth. A deletion downstream of this gene, which causes reduced sclerostin expression, is associated with a milder form of the disorder called van Buchem disease. [provided by RefSeq].

NCBI Gene ID

50964

Swiss Prot

Q9BQB4

Accession Number

Q9BQB4

Host

Rabbit

Reactivity

Human, Mouse

Immunogen

This SOST antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 38-66 amino acids from the N-terminal region of human SOST.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cell Cycle, Signal Transduction

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Homology

Predicted species reactivity based on immunogen sequence: Bovine

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

24 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:500

Symbol

SOST

NCBI Official Name

Sclerostin

NCBI Organism

Homo sapiens

Background Reference 01

Van Lierop, A.H., et al. Eur. J. Endocrinol. 163 (5) :833-837 (2010)

Background Reference 02

Liu, J.M., et al. J. Clin. Endocrinol. Metab. 95 (9), E112-E120 (2010) :

Background Reference 03

Paternoster, L., et al. J. Clin. Endocrinol. Metab. 95 (8) :3940-3948 (2010)

Background Reference 04

Piters, E., et al. Hum. Mutat. 31 (7), E1526-E1543 (2010) :

Other Product Names

Sclerostin, SOST

Tested Applications

Protein ID

20140220

Physical Properties

Liquid

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