PDE6D Antibody

Product Specifications

Background

Acts as a GTP specific dissociation inhibitor (GDI) . Increases the affinity of ARL3 for GTP by several orders of magnitude and does so by decreasing the nucleotide dissociation rate. Stabilizes Arl3-GTP by decreasing the nucleotide dissociation.

NCBI Gene ID

5147

Swiss Prot

O43924

Accession Number

O43924

Host

Rabbit

Reactivity

Human, Mouse

Immunogen

This PDE6D antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 26-55 amino acids from the Central region of human PDE6D.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Neuroscience, Signal Transduction

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Homology

Predicted species reactivity based on immunogen sequence: Bovine

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

17 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

PDE6D

NCBI Official Name

Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta

NCBI Organism

Homo sapiens

Background Reference 01

Gudbjartsson, D.F., et al. Nat. Genet. 40 (5) :609-615 (2008)

Background Reference 02

Wilson, S.J., et al. J. Biol. Chem. 281 (17) :11780-11786 (2006)

Background Reference 03

Stelzl, U., et al. Cell 122 (6) :957-968 (2005)

Background Reference 04

Hanzal-Bayer, M., et al. EMBO J. 21 (9) :2095-2106 (2002)

Other Product Names

Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta, GMP-PDE delta, Protein p17, PDE6D, PDED

Tested Applications

Physical Properties

Liquid

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