SAFB Antibody
Product Specifications
Background
This gene encodes a DNA-binding protein that has high specificity for scaffold or matrix attachment region DNA elements (S/MAR DNA) . This protein is thought to be involved in attaching the base of chromatin loops to the nuclear matrix but there is conflicting evidence as to whether this protein is a component of chromatin or a nuclear matrix protein. Scaffold attachment factors are a specific subset of nuclear matrix proteins (NMP) that specifically bind to S/MAR. This encoded protein is thought to serve as a molecular base to assemble a 'transcriptosome complex' in the vicinity of actively transcribed genes. It is involved in the regulation of the heat shock protein 27 transcription and also can act as an estrogen receptor corepressor. This gene is a candidate gene for breast tumorigenesis.
NCBI Gene ID
6294
Swiss Prot
Q15424
Accession Number
Q15424
Host
Rabbit
Reactivity
Human
Immunogen
This SAFB antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 65-94 amino acids from the N-terminal region of human SAFB.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Other
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Product Datasheet
https://www.prosci-inc.com/?datasheet_sku=59-146
Calculated Molecular Weight
103 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
SAFB
NCBI Official Name
Scaffold attachment factor B1
NCBI Organism
Homo sapiens
Background Reference 01
Hammerich-Hille, S., et al. Breast Cancer Res. Treat. 121 (2) :503-509 (2010)
Background Reference 02
Hammerich-Hille, S., et al. J. Biol. Chem. 285 (6) :3608-3616 (2010)
Background Reference 03
Tsianou, D., et al. FEBS J. 276 (18) :5212-5227 (2009)
Background Reference 04
Chen, H., et al. Endocrinology 150 (5) :2429-2435 (2009)
Other Product Names
Scaffold attachment factor B1, SAF-B, SAF-B1, HSP27 estrogen response element-TATA box-binding protein, HSP27 ERE-TATA-binding protein, SAFB, HAP, HET, SAFB1
Tested Applications
WB
Protein ID
116242782
Physical Properties
Liquid
Curated Selection
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