NPLOC4 Antibody

Product Specifications

Background

The ternary complex containing UFD1L, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The NPLOC4-UFD1L-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope (By similarity) .

NCBI Gene ID

55666

Swiss Prot

Q8TAT6

Accession Number

Q8TAT6

Host

Rabbit

Reactivity

Human

Immunogen

This NPLOC4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 456-484 amino acids from the C-terminal region of human NPLOC4.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Signal Transduction

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Homology

Predicted species reactivity based on immunogen sequence: Mouse, Rat

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

68 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

NPLOC4

NCBI Official Name

Nuclear protein localization protein 4 homolog

NCBI Organism

Homo sapiens

Background Reference 01

Liu, F., et al. PLoS Genet. 6, E1000934 (2010) :

Background Reference 02

Lass, A., et al. Exp. Cell Res. 314 (14) :2715-2723 (2008)

Background Reference 03

McConnell, E., et al. Biochem. Biophys. Res. Commun. 355 (4) :1087-1090 (2007)

Background Reference 04

Gevaert, K., et al. Nat. Biotechnol. 21 (5) :566-569 (2003)

Other Product Names

Nuclear protein localization protein 4 homolog, Protein NPL4, NPLOC4, KIAA1499, NPL4

Tested Applications

Protein ID

50428974

Physical Properties

Liquid

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