MR1 Antibody

Product Specifications

Background

MR1 has antigen presentation function. Involved in the development and expansion of a small population of T cells expressing an invariant T cell receptor alpha chain called mucosal-associated invariant T cells (MAIT) . MAIT cells are preferentially located in the gut lamina propria and therfore may be involed in monitoring commensal flora or serve as a distress signal. Expression and MAIT cell recognition seem to be ligand-dependent.

NCBI Gene ID

3140

Swiss Prot

Q95460

Accession Number

Q95460

Host

Rabbit

Reactivity

Human

Immunogen

This MR1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 312-341 amino acids from the C-terminal region of human MR1.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Immunology

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

39 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

MR1

NCBI Official Name

Major histocompatibility complex class I-related gene protein

NCBI Organism

Homo sapiens

Background Reference 01

Gozalbo-Lopez, B., et al. Histol. Histopathol. 24 (11) :1439-1449 (2009)

Background Reference 02

Stumpf, A.N., et al. Blood 114 (17) :3684-3692 (2009)

Background Reference 03

Huang, S., et al. Proc. Natl. Acad. Sci. U.S.A. 106 (20) :8290-8295 (2009)

Background Reference 04

Aldemir, H. Biochem. Biophys. Res. Commun. 366 (2) :328-334 (2008)

Other Product Names

Major histocompatibility complex class I-related gene protein, MHC class I-related gene protein, Class I histocompatibility antigen-like protein, MR1

Tested Applications

Protein ID

74751679

Physical Properties

Liquid

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