KLHL12 Antibody

Product Specifications

Background

Serves as a substrate-specific adapter for the CUL3-based ubiquitin-protein E3 ligase complex. Negatively regulates the Wnt signaling pathway via the targeted ubiquitination and subsequent proteolysis of DVL3.

NCBI Gene ID

59349

Swiss Prot

Q53G59

Accession Number

Q53G59

Host

Rabbit

Reactivity

Human, Mouse

Immunogen

This KLHL12 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 376-404 amino acids from the C-terminal region of human KLHL12.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Other

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Homology

Predicted species reactivity based on immunogen sequence: Bovine, Zebrafish, Rat, Xenopus

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

63 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

KLHL12

NCBI Official Name

Kelch-like protein 12

NCBI Organism

Homo sapiens

Background Reference 01

Ehret, G.B., et al. Eur. J. Hum. Genet. 17 (12) :1650-1657 (2009)

Background Reference 02

Rondou, P., et al. J. Biol. Chem. 283 (17) :11083-11096 (2008)

Background Reference 03

Lim, J., et al. Cell 125 (4) :801-814 (2006)

Background Reference 04

Angers, S., et al. Nat. Cell Biol. 8 (4) :348-357 (2006)

Other Product Names

Kelch-like protein 12, CUL3-interacting protein 1, DKIR homolog, hDKIR, KLHL12, C3IP1

Tested Applications

Protein ID

97054498

Physical Properties

Liquid

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