Mouse Tlk1 Antibody

Product Specifications

Background

Rapidly and transiently inhibited by phosphorylation following the generation of DNA double-stranded breaks during S-phase. This is cell cycle checkpoint and ATM-pathway dependent and appears to regulate processes involved in chromatin assembly (By similarity) . Isoform 3 protects the cells from the ionizing radiation by faciliting the repair of DSBs. In vitro, phosphorylates histone H3 at 'Ser-10' (By similarity) .

NCBI Gene ID

228012

Swiss Prot

Q8C0V0

Accession Number

Q8C0V0

Host

Rabbit

Reactivity

Mouse

Immunogen

This Mouse Tlk1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 701-728 amino acids from the C-terminal region of mouse Tlk1.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Signal Transduction

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Homology

Predicted species reactivity based on immunogen sequence: Human

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

87 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

Tlk1

NCBI Official Name

Serine/threonine-protein kinase tousled-like 1

NCBI Organism

Mus musculus

Background Reference 01

Canfield, C., et al. BMC Mol. Biol. 10, 110 (2009) :

Background Reference 02

Taniwaki, T., et al. Dev. Growth Differ. 47 (3) :163-172 (2005)

Background Reference 03

Sunavala-Dossabhoy, G., et al. BMC Mol. Biol. 6, 19 (2005) :

Background Reference 04

Cobellis, G., et al. Nucleic Acids Res. 33 (4), E44 (2005) :

Other Product Names

Serine/threonine-protein kinase tousled-like 1, Tousled-like kinase 1, Tlk1

Tested Applications

Physical Properties

Liquid

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