RRN3 Antibody

Product Specifications

Background

Required for efficient transcription initiation by RNA polymerase I. Required for the formation of the competent preinitiation complex (PIC) . Dissociates from pol I as a consequence of transcription. In vitro, cannot activate transcription in a subsequent transcription reaction (By similarity) .

NCBI Gene ID

54700

Swiss Prot

Q9NYV6

Accession Number

Q9NYV6

Host

Rabbit

Reactivity

Human

Immunogen

This RRN3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 277-305 amino acids from the Central region of human RRN3.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Signal Transduction

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

74 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

RRN3

NCBI Official Name

RNA polymerase I-specific transcription initiation factor RRN3

NCBI Organism

Homo sapiens

Background Reference 01

Bierhoff, H., et al. Mol. Cell. Biol. 28 (16) :4988-4998 (2008)

Background Reference 02

Amit, M., et al. BMC Mol. Biol. 8, 109 (2007) :

Background Reference 03

Mayer, C., et al. Genes Dev. 18 (4) :423-434 (2004)

Background Reference 04

Hirschler-Laszkiewicz, I., et al. J. Biol. Chem. 278 (21) :18953-18959 (2003)

Other Product Names

RNA polymerase I-specific transcription initiation factor RRN3, Transcription initiation factor IA, TIF-IA, RRN3, TIFIA

Tested Applications

Protein ID

74719591

Physical Properties

Liquid

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