COL4A6 Antibody
Product Specifications
Background
This gene encodes one of the six subunits of type IV collagen, the major structural component of basement membranes. Like the other members of the type IV collagen gene family, this gene is organized in a head-to-head conformation with another type IV collagen gene, alpha 5 type IV collagen, so that the gene pair shares a common promoter. Deletions in the alpha 5 gene that extend into the alpha 6 gene result in diffuse leiomyomatosis accompanying the X-linked Alport syndrome caused by the deletion in the alpha 5 gene. Two splice variants have been identified for this gene.
NCBI Gene ID
1288
Swiss Prot
Q14031
Accession Number
Q14031
Host
Rabbit
Reactivity
Human
Immunogen
This COL4A6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 830-859 amino acids from the Central region of human COL4A6.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
164 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
COL4A6
NCBI Official Name
Collagen alpha-6 (IV) chain
NCBI Organism
Homo sapiens
Background Reference 01
Romero, R., et al. Am. J. Obstet. Gynecol. (2010) In press :
Background Reference 02
Bailey, S.D., et al. Diabetes Care (2010) In press :
Background Reference 03
Romero, R., et al. Am. J. Obstet. Gynecol. 202 (5), 431 (2010) :
Background Reference 04
Talmud, P.J., et al. Am. J. Hum. Genet. 85 (5) :628-642 (2009)
Other Product Names
Collagen alpha-6 (IV) chain, COL4A6
Tested Applications
WB
Protein ID
116241307
Physical Properties
Liquid
Curated Selection
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