ASB2 Antibody
Product Specifications
Background
The protein encoded by this gene is a member of the ankyrin repeat and SOCS box-containing (ASB) family of proteins. They contain ankyrin repeat sequence and SOCS box domain. The SOCS box serves to couple suppressor of cytokine signalling (SOCS) proteins and their binding partners with the elongin B and C complex, possibly targeting them for degradation. This gene is induced by all-trans retinoic acid. In myeloid leukemia cells, the expression of this encoded protein has been shown to induce growth inhibition and chromatin condensation. Multiple alternatively spliced transcript variants have been described for this gene but their full length sequences are not known.
NCBI Gene ID
51676
Swiss Prot
Q96Q27
Accession Number
Q96Q27
Host
Rabbit
Reactivity
Human
Immunogen
This ASB2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 58-86 amino acids from the N-terminal region of human ASB2.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cell Cycle
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
65 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
ASB2
NCBI Official Name
Ankyrin repeat and SOCS box protein 2
NCBI Organism
Homo sapiens
Background Reference 01
Heuze, M.L., et al. Blood 112 (13) :5130-5140 (2008)
Background Reference 02
Kohroki, J., et al. FEBS Lett. 579 (30) :6796-6802 (2005)
Background Reference 03
Heuze, M.L., et al. J. Biol. Chem. 280 (7) :5468-5474 (2005)
Background Reference 04
Colland, F., et al. Genome Res. 14 (7) :1324-1332 (2004)
Other Product Names
Ankyrin repeat and SOCS box protein 2, ASB-2, ASB2
Tested Applications
WB
Protein ID
20531999
Physical Properties
Liquid
Curated Selection
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