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EXOSC4 Antibody

Product Specifications

Background

Component of the exosome 3'->5' exoribonuclease complex, a complex that degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3'-untranslated regions. Required for the 3'-processing of the 7S pre-RNA to the mature 5.8S rRNA. Has a 3'-5' exonuclease activity. Plays a role in replication-dependent histone mRNA degradation.

NCBI Gene ID

54512

Swiss Prot

Q9NPD3

Accession Number

Q9NPD3

Host

Rabbit

Reactivity

Human

Immunogen

This EXOSC4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 69-96 amino acids from the Central region of human EXOSC4.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Other

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Homology

Predicted species reactivity based on immunogen sequence: Bovine, Mouse

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

26 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

EXOSC4

NCBI Official Name

Exosome complex component RRP41

NCBI Organism

Homo sapiens

Background Reference 01

Mullen, T.E., et al. Genes Dev. 22 (1) :50-65 (2008)

Background Reference 02

Van Dijk, E.L., et al. RNA 13 (7) :1027-1035 (2007)

Background Reference 03

Oh, J.H., et al. Mamm. Genome 16 (12) :942-954 (2005)

Background Reference 04

Andersen, J.S., et al. Nature 433 (7021) :77-83 (2005)

Other Product Names

Exosome complex component RRP41, Exosome component 4, Ribosomal RNA-processing protein 41, p12A, EXOSC4, RRP41, SKI6

Tested Applications

WB

Protein ID

14285756

Physical Properties

Liquid

Frequently Asked Questions

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