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LOXL4 Antibody

Product Specifications

Background

This gene encodes a member of the lysyl oxidase gene family. The prototypic member of the family is essential to the biogenesis of connective tissue, encoding an extracellular copper-dependent amine oxidase that catalyses the first step in the formation of crosslinks in collagens and elastin. A highly conserved amino acid sequence at the C-terminus end appears to be sufficient for amine oxidase activity, suggesting that each family member may retain this function. The N-terminus is poorly conserved and may impart additional roles in developmental regulation, senescence, tumor suppression, cell growth control, and chemotaxis to each member of the family.

NCBI Gene ID

84171

Swiss Prot

Q96JB6

Accession Number

Q96JB6

Host

Rabbit

Reactivity

Human, Mouse

Immunogen

This LOXL4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 575-603 amino acids from the C-terminal region of human LOXL4.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cancer, Signal Transduction

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Product Datasheet

https://www.prosci-inc.com/?datasheet_sku=59-061

Calculated Molecular Weight

84 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

LOXL4

NCBI Official Name

Lysyl oxidase homolog 4

NCBI Organism

Homo sapiens

Background Reference 01

Venkatesan, K., et al. Nat. Methods 6 (1) :83-90 (2009)

Background Reference 02

Sebban, S., et al. Virchows Arch. 454 (1) :71-79 (2009)

Background Reference 03

Gorogh, T., et al. Int. J. Oncol. 33 (5) :1091-1098 (2008)

Background Reference 04

Kim, D.J., et al. Biochem. Biophys. Res. Commun. 373 (4) :521-527 (2008)

Other Product Names

Lysyl oxidase homolog 4, 143-, Lysyl oxidase-like protein 4, Lysyl oxidase-related protein C, LOXL4, LOXC

Tested Applications

WB

Protein ID

20177960

Physical Properties

Liquid

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