SRRT Antibody

Product Specifications

Background

SRRT acts as a mediator between the cap-binding complex (CBC) and the primary microRNAs (miRNAs) processing machinery during cell proliferation. Contributes to the stability and delivery of capped primary miRNA transcripts to the primary miRNA processing complex containing DGCR8 and RNASEN, thereby playing a role in RNA-mediated gene silencing (RNAi) by miRNAs. Binds capped RNAs (m7GpppG-capped RNA) ; however interaction is probably mediated via its interaction with NCBP1/CBP80 component of the CBC complex. Involved in cell cycle progression at S phase. Does not directly confer arsenite resistance but rather modulates arsenic sensitivity.

NCBI Gene ID

51593

Swiss Prot

Q9BXP5

Accession Number

Q9BXP5

Host

Rabbit

Reactivity

Human

Immunogen

This SRRT antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 54-81 amino acids from the N-terminal region of human SRRT.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cell Cycle, Obesity, Signal Transduction

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Homology

Predicted species reactivity based on immunogen sequence: Bovine, Mouse

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

101 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

SRRT

NCBI Official Name

Serrate RNA effector molecule homolog

NCBI Organism

Homo sapiens

Background Reference 01

Eijgelsheim, M., et al. Hum. Mol. Genet. 19 (19) :3885-3894 (2010)

Background Reference 02

Kiriyama, M., et al. Mol. Cell. Biol. 29 (17) :4729-4741 (2009)

Background Reference 03

Gruber, J.J., et al. Cell 138 (2) :328-339 (2009)

Background Reference 04

Wilson, M.D., et al. Mol. Cell. Biol. 28 (5) :1503-1514 (2008)

Other Product Names

Serrate RNA effector molecule homolog, Arsenite-resistance protein 2, SRRT, ARS2, ASR2

Tested Applications

Protein ID

20137457

Physical Properties

Liquid

Curated Selection

Explore Other Products

Discover premium biology products from our extensive collection of 20M+ items

MBS3906185-01 0.5 mg

Goat anti-Guinea pig IgG Heavy and Light Chain Antibody DyLight 650 Conjugated

Ask

View Details

MBS3906185-02 5x 0.5 mg

Goat anti-Guinea pig IgG Heavy and Light Chain Antibody DyLight 650 Conjugated

Ask

View Details

MBS2036342-01 0.1 mL

HRP-Linked Polyclonal Antibody to Interleukin 12B (IL12B)

Ask

View Details

MBS2036342-02 0.2 mL

HRP-Linked Polyclonal Antibody to Interleukin 12B (IL12B)

Ask

View Details

MBS2036342-03 0.5 mL

HRP-Linked Polyclonal Antibody to Interleukin 12B (IL12B)

Ask

View Details

MBS2036342-04 1 mL

HRP-Linked Polyclonal Antibody to Interleukin 12B (IL12B)

Ask

View Details