OS9 Antibody

Product Specifications

Background

This gene encodes a protein that is highly expressed in osteosarcomas. This protein binds to the hypoxia-inducible factor 1 (HIF-1), a key regulator of the hypoxic response and angiogenesis, and promotes the degradation of one of its subunits. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

NCBI Gene ID

10956

Swiss Prot

Q13438

Accession Number

Q13438

Host

Rabbit

Reactivity

Human

Immunogen

This OS9 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 521-549 amino acids from the C-terminal region of human OS9.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cancer, Obesity

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Homology

Predicted species reactivity based on immunogen sequence: Bovine

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

76 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

OS9

NCBI Official Name

Protein OS-9

NCBI Organism

Homo sapiens

Background Reference 01

Feng, T., et al. Hum. Genet. 128 (3) :269-280 (2010)

Background Reference 02

Mikami, K., et al. Glycobiology 20 (3) :310-321 (2010)

Background Reference 03

Hosokawa, N., et al. J. Biol. Chem. 284 (25) :17061-17068 (2009)

Background Reference 04

Jansen, B.J., et al. Mol. Immunol. 46 (4) :505-515 (2009)

Other Product Names

Protein OS-9, Amplified in osteosarcoma 9, OS9

Tested Applications

Protein ID

3024310

Physical Properties

Liquid

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