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SGCA Antibody

Product Specifications

Background

This gene encodes a component of the dystrophin-glycoprotein complex (DGC), which is critical to the stability of muscle fiber membranes and to the linking of the actin cytoskeleton to the extracellular matrix. Its expression is thought to be restricted to striated muscle. Mutations in this gene result in type 2D autosomal recessive limb-girdle muscular dystrophy. Multiple transcript variants encoding different isoforms have been found for this gene.

NCBI Gene ID

6442

Swiss Prot

Q16586

Accession Number

Q16586

Host

Rabbit

Reactivity

Human

Immunogen

This SGCA antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 239-266 amino acids from the Central region of human SGCA.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Signal Transduction

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Product Datasheet

https://www.prosci-inc.com/?datasheet_sku=59-032

Calculated Molecular Weight

43 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

SGCA

NCBI Official Name

Alpha-sarcoglycan

NCBI Organism

Homo sapiens

Background Reference 01

Mendell, J.R., et al. Ann. Neurol. 68 (5) :629-638 (2010)

Background Reference 02

Fernandez, K., et al. Am. J. Pathol. 176 (1) :416-434 (2010)

Background Reference 03

Klinge, L., et al. Neuromuscul. Disord. 18 (12) :934-941 (2008)

Background Reference 04

Delgado-Olguin, P., et al. Biochim. Biophys. Acta 1779 (1) :74-80 (2008)

Other Product Names

Alpha-sarcoglycan, Alpha-SG, 50 kDa dystrophin-associated glycoprotein, 50DAG, Adhalin, Dystroglycan-2, SGCA, ADL, DAG2

Tested Applications

WB

Physical Properties

Liquid

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