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RHD Antibody

Product Specifications

Background

The Rh blood group system is the second most clinically significant of the blood groups, second only to ABO. It is also the most polymorphic of the blood groups, with variations due to deletions, gene conversions, and missense mutations. The Rh blood group includes this gene, which encodes the RhD protein, and a second gene that encodes both the RhC and RhE antigens on a single polypeptide. The two genes, and a third unrelated gene, are found in a cluster on chromosome 1. The classification of Rh-positive and Rh-negative individuals is determined by the presence or absence of the highly immunogenic RhD protein on the surface of erythrocytes. Multiple transcript variants encoding different isoforms have been found for this gene.

NCBI Gene ID

6007

Swiss Prot

Q02161

Accession Number

Q02161

Host

Rabbit

Reactivity

Human

Immunogen

This RHD antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 173-201 amino acids from the Central region of human RHD.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Immunology

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Product Datasheet

https://www.prosci-inc.com/?datasheet_sku=59-029

Calculated Molecular Weight

45 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

RHD

NCBI Official Name

Blood group Rh (D) polypeptide

NCBI Organism

Homo sapiens

Background Reference 01

Flegr, J., et al. Folia Parasitol. 57 (2) :143-150 (2010)

Background Reference 02

Liu, H.C., et al. Biochim. Biophys. Acta 1800 (6) :565-573 (2010)

Background Reference 03

Schmid, P., et al. Transfusion 50 (1) :267-269 (2010)

Background Reference 04

Wang, X.D., et al. Eur. J. Clin. Invest. 39 (7) :607-617 (2009)

Other Product Names

Blood group Rh (D) polypeptide, RHXIII, Rh polypeptide 2, RhPII, Rhesus D antigen, CD240D, RHD

Tested Applications

WB

Protein ID

296452980

Physical Properties

Liquid

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