PDE4A Antibody

Product Specifications

Background

Cyclic nucleotides are important second messengers that regulate and mediate a number of cellular responses to extracellular signals, such as hormones, light, and neurotransmitters. Cyclic nucleotide phosphodiesterases (PDEs) regulate the cellular concentrations of cyclic nucleotides and thereby play a role in signal transduction. PDE4A is a class IV cAMP-specific PDE (summary by Milatovich et al., 1994 [PubMed 8009369]) .

NCBI Gene ID

5141

Swiss Prot

P27815

Accession Number

P27815

Host

Rabbit

Reactivity

Human, Mouse

Immunogen

This PDE4A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 32-61 amino acids from the N-terminal region of human PDE4A.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cell Cycle, Signal Transduction

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

98 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

PDE4A

NCBI Official Name

CAMP-specific 3',5'-cyclic phosphodiesterase 4A

NCBI Organism

Homo sapiens

Background Reference 01

Bailey, S.D., et al. Diabetes Care 33 (10) :2250-2253 (2010)

Background Reference 02

Selige, J., et al. J. Cell. Physiol. 223 (2) :317-326 (2010)

Background Reference 03

Bjorgo, E., et al. Mol. Cell. Biol. 30 (7) :1660-1672 (2010)

Background Reference 04

Singh, D., et al. Respir. Res. 11, 26 (2010) :

Other Product Names

CAMP-specific 3',5'-cyclic phosphodiesterase 4A, DPDE2, PDE46, PDE4A, DPDE2

Tested Applications

Protein ID

116242706

Physical Properties

Liquid

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