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TNNI3 Antibody

Product Specifications

Background

Troponin I (TnI), along with troponin T (TnT) and troponin C (TnC), is one of 3 subunits that form the troponin complex of the thin filaments of striated muscle. TnI is the inhibitory subunit; blocking actin-myosin interactions and thereby mediating striated muscle relaxation. The TnI subfamily contains three genes: TnI-skeletal-fast-twitch, TnI-skeletal-slow-twitch, and TnI-cardiac. This gene encodes the TnI-cardiac protein and is exclusively expressed in cardiac muscle tissues. Mutations in this gene cause familial hypertrophic cardiomyopathy type 7 (CMH7) and familial restrictive cardiomyopathy (RCM) .

NCBI Gene ID

7137

Swiss Prot

P19429

Accession Number

P19429

Host

Rabbit

Reactivity

Human, Mouse

Immunogen

This TNNI3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 86-114 amino acids from the Central region of human TNNI3.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cell Cycle, Signal Transduction

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Product Datasheet

https://www.prosci-inc.com/?datasheet_sku=59-004

Calculated Molecular Weight

24 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

TNNI3

NCBI Official Name

Troponin I, cardiac muscle

NCBI Organism

Homo sapiens

Background Reference 01

Millat, G., et al. Clin. Chim. Acta 411 (23-24), 1983-1991 (2010) :

Background Reference 02

Murakami, C., et al. Leg Med (Tokyo) 12 (6) :280-283 (2010)

Background Reference 03

Millat, G., et al. EurMed Genet 53 (5) :261-267 (2010)

Background Reference 04

Di Chiara, A., et al.Cardiovasc Med (Hagerstown) 11 (8) :587-592 (2010)

Other Product Names

Troponin I, cardiac muscle, Cardiac troponin I, TNNI3, TNNC1

Tested Applications

WB

Protein ID

136213

Physical Properties

Liquid

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