Bmp6 Antibody

Product Specifications

Background

The bone morphogenetic proteins (BMPs) are a family of secreted signaling molecules that can induce ectopic bone growth. Many BMPs are part of the transforming growth factor-beta (TGFB) superfamily. BMPs were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site. Based on its expression early in embryogenesis, Bmp6 has a proposed role in early development. In addition, the fact that BMP6 is closely related to BMP5 and BMP7 has lead to speculation of possible bone inductive activity.

NCBI Gene ID

654

Swiss Prot

P22004

Accession Number

P22004

Host

Rabbit

Reactivity

Human

Immunogen

This Bmp6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 25-55 amino acids from the N-terminal region of human Bmp6.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cell Cycle, Cell Cycle, Signal Transduction

Purification

This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

57 kDa

Fragment

Rabbit Ig

Symbol

BMP6

NCBI Official Name

Bone morphogenetic protein 6

NCBI Organism

Homo sapiens

Background Reference 01

Lories, R.J., et al., Arthritis Rheum. 48 (10) :2807-2818 (2003) .

Background Reference 02

Bobacz, K., et al., Arthritis Rheum. 48 (9) :2501-2508 (2003) .

Background Reference 03

Tamada, H., et al., Biochim. Biophys. Acta 1395 (3) :247-251 (1998) .

Background Reference 04

Rickard, D.J., et al., J. Clin. Invest. 101 (2) :413-422 (1998) .

Other Product Names

Bone morphogenetic protein 6, BMP-6, VG-1-related protein, VG-1-R, VGR-1, BMP6, VGR

Tested Applications

WB, IHC-P

Protein ID

115076

Physical Properties

Liquid

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