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CLCN3 Antibody

Product Specifications

Background

CLCN3 mediates the exchange of chloride ions against protons. Functions as antiporter and contributes to the acidification of the endosome and synaptic vesicle lumen, and may thereby affect vesicle trafficking and exocytosis. May play an important role in neuronal cell function through regulation of membrane excitability by protein kinase C. It could help neuronal cells to establish short-term memory.

NCBI Gene ID

1182

Swiss Prot

P51790

Accession Number

P51790

Host

Rabbit

Reactivity

Human

Immunogen

This CLCN3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 285-313 amino acids from the Central region of human CLCN3.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Obesity, Neuroscience, Signal Transduction

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Homology

Predicted species reactivity based on immunogen sequence: Mouse, Rabbit, Rat

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

91 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

CLCN3

NCBI Official Name

H (+) /Cl (-) exchange transporter 3

NCBI Organism

Homo sapiens

Background Reference 01

Cuddapah, V.A., et al. J. Biol. Chem. 285 (15) :11188-11196 (2010)

Background Reference 02

Xiong, D., et al. Clin. Exp. Pharmacol. Physiol. 36 (4) :386-393 (2009)

Background Reference 03

Yin, Z., et al. Am. J. Physiol., Cell Physiol. 294 (2), C535-C542 (2008) :

Background Reference 04

Matsuda, J.J., et al. Am. J. Physiol., Cell Physiol. 294 (1), C251-C262 (2008) :

Other Product Names

H (+) /Cl (-) exchange transporter 3, Chloride channel protein 3, ClC-3, Chloride transporter ClC-3, CLCN3

Tested Applications

WB

Protein ID

226693513

Physical Properties

Liquid

Frequently Asked Questions

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