PPT1 Antibody

Product Specifications

Background

The protein encoded by this gene is a small glycoprotein involved in the catabolism of lipid-modified proteins during lysosomal degradation. The encoded enzyme removes thioester-linked fatty acyl groups such as palmitate from cysteine residues. Defects in this gene are a cause of infantile neuronal ceroid lipofuscinosis 1 (CLN1, or INCL) and neuronal ceroid lipofuscinosis 4 (CLN4) . Two transcript variants encoding different isoforms have been found for this gene.

NCBI Gene ID

5538

Swiss Prot

P50897

Accession Number

P50897

Host

Rabbit

Reactivity

Human

Immunogen

This PPT1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 189-217 amino acids from the Central region of human PPT1.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Obesity, Signal Transduction

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Homology

Predicted species reactivity based on immunogen sequence: Monkey

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

34 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

PPT1

NCBI Official Name

Palmitoyl-protein thioesterase 1

NCBI Organism

Homo sapiens

Background Reference 01

Ohno, K., et al. Brain Dev. 32 (7) :524-530 (2010)

Background Reference 02

Simonati, A., et al. Pediatr. Neurol. 40 (4) :271-276 (2009)

Background Reference 03

Martins-de-Souza, D., et al. Eur Arch Psychiatry Clin Neurosci 259 (3) :151-163 (2009)

Background Reference 04

Kousi, M., et al. Brain 132 (PT 3), 810-819 (2009) :

Other Product Names

Palmitoyl-protein thioesterase 1, PPT-1, Palmitoyl-protein hydrolase 1, PPT1, PPT

Tested Applications

Protein ID

1709747

Physical Properties

Liquid

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