Bmp1 Antibody

Product Specifications

Background

The BMP1 locus encodes a protein that is capable of inducing formation of cartilage in vivo. Although other bone morphogenetic proteins are members of the TGF-beta superfamily, BMP1 encodes a protein that is not closely related to other known growth factors. BMP1 protein and procollagen C proteinase (PCP), a secreted metalloprotease requiring calcium and needed for cartilage and bone formation, are identical. PCP or BMP1 protein cleaves the C-terminal propeptides of procollagen I, II, and III and its activity is increased by the procollagen C-endopeptidase enhancer protein. The BMP1 gene is expressed as alternatively spliced variants that share an N-terminal protease domain but differ in their C-terminal region.

NCBI Gene ID

649

Swiss Prot

P13497

Accession Number

P13497

Host

Rabbit

Reactivity

Mouse

Immunogen

This Bmp1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 957-986 amino acids from the C-terminal region of human Bmp1.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cancer, Cell Cycle, Obesity, Signal Transduction

Purification

This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Product Datasheet

https://www.prosci-inc.com/?datasheet_sku=58-970

Calculated Molecular Weight

111 kDa

Fragment

Rabbit Ig

Symbol

BMP1

NCBI Official Name

Bone morphogenetic protein 1

NCBI Organism

Homo sapiens

Background Reference 01

Leighton, M., et al., J. Biol. Chem. 278 (20) :18478-18484 (2003) .

Background Reference 02

Hartigan, N., et al., J. Biol. Chem. 278 (20) :18045-18049 (2003) .

Background Reference 03

Garrigue-Antar, L., et al., J. Biol. Chem. 277 (45) :43327-43334 (2002) .

Background Reference 04

Rattenholl, A., et al., J. Biol. Chem. 277 (29) :26372-26378 (2002) .

Other Product Names

Bone morphogenetic protein 1, BMP-1, Mammalian tolloid protein, mTld, Procollagen C-proteinase, PCP, BMP1, PCOLC

Tested Applications

WB, IHC-P

Protein ID

13124688

Physical Properties

Liquid

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