P2RX6 Antibody

Product Specifications

Background

The protein encoded by this gene belongs to the family of P2X receptors, which are ATP-gated ion channels and mediate rapid and selective permeability to cations. This gene is predominantly expressed in skeletal muscle, and regulated by p53. The encoded protein is associated with VE-cadherin at the adherens junctions of human umbilical vein endothelial cells. Alternative splicing results in multiple transcript variants. A related pseudogene, which is also located on chromosome 22, has been identified.

NCBI Gene ID

9127

Swiss Prot

O15547

Accession Number

O15547

Host

Rabbit

Reactivity

Human

Immunogen

This P2RX6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 198-226 amino acids from the Central region of human P2RX6.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Neuroscience, Signal Transduction

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

49 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

P2RX6

NCBI Official Name

P2X purinoceptor 6

NCBI Organism

Homo sapiens

Background Reference 01

Trynka, G., et al. Gut 58 (8) :1078-1083 (2009)

Background Reference 02

Luke, M.M., et al. Stroke 40 (2) :363-368 (2009)

Background Reference 03

Palomino-Doza, J., et al. Hypertension 52 (5) :980-985 (2008)

Background Reference 04

Shiffman, D., et al. Arterioscler. Thromb. Vasc. Biol. 28 (1) :173-179 (2008)

Other Product Names

P2X purinoceptor 6, P2X6, ATP receptor, P2XM, Purinergic receptor, Purinergic receptor P2X-like 1, P2RX6, P2RXL1, P2X6

Tested Applications

Physical Properties

Liquid

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