SOCS7 Antibody

Product Specifications

Background

Regulates signaling cascades probably through protein ubiquitination and/or sequestration. Functions in insulin signaling and glucose homeostasis through IRS1 ubiquitination and subsequent proteasomal degradation. Inhibits also prolactin, growth hormone and leptin signaling by preventing STAT3 and STAT5 activation, sequestering them in the cytoplasm and reducing their binding to DNA. May be a substrate recognition component of a SCF-like E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity) .

NCBI Gene ID

30837

Swiss Prot

O14512

Accession Number

O14512

Host

Rabbit

Reactivity

Human

Immunogen

This SOCS7 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 458-486 amino acids from the C-terminal region of human SOCS7.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Signal Transduction

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Homology

Predicted species reactivity based on immunogen sequence: Mouse

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

63 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

SOCS7

NCBI Official Name

Suppressor of cytokine signaling 7

NCBI Organism

Homo sapiens

Background Reference 01

Pazienza, V., et al. J. Gen. Virol. 91 (PT 7), 1678-1686 (2010) :

Background Reference 02

Sasi, W., et al. BMC Cancer 10, 178 (2010) :

Background Reference 03

Kremer, B.E., et al. Cell 130 (5) :837-850 (2007)

Background Reference 04

Zody, M.C., et al. Nature 440 (7087) :1045-1049 (2006)

Other Product Names

Suppressor of cytokine signaling 7, SOCS-7, Nck, Ash and phospholipase C gamma-binding protein, Nck-associated protein 4, NAP-4, SOCS7, NAP4, SOCS6

Tested Applications

Physical Properties

Liquid

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