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CHRNG Antibody

Product Specifications

Background

The mammalian muscle-type acetylcholine receptor is a transmembrane pentameric glycoprotein with two alpha subunits, one beta, one delta, and one epsilon (in adult skeletal muscle) or gamma (in fetal and denervated muscle) subunit. This gene, which encodes the gamma subunit, is expressed prior to the thirty-third week of gestation in humans. The gamma subunit of the acetylcholine receptor plays a role in neuromuscular organogenesis and ligand binding and disruption of gamma subunit expression prevents the correct localization of the receptor in cell membranes. Mutations in this gene cause Escobar syndrome and a lethal form of multiple pterygium syndrome. Muscle-type acetylcholine receptor is the major antigen in the autoimmune disease myasthenia gravis.

NCBI Gene ID

1146

Swiss Prot

P07510

Accession Number

P07510

Host

Rabbit

Reactivity

Human

Immunogen

This CHRNG antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 22-50 amino acids from the N-terminal region of human CHRNG.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Neuroscience

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Product Datasheet

https://www.prosci-inc.com/?datasheet_sku=58-950

Calculated Molecular Weight

58 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

CHRNG

NCBI Official Name

Acetylcholine receptor subunit gamma

NCBI Organism

Homo sapiens

Background Reference 01

Saccone, N.L., et al. Genes Brain Behav. (2010) In press :

Background Reference 02

Gratacos, M., et al. Am. J. Med. Genet.Neuropsychiatr. Genet. 150B (6), 808-816 (2009) :

Background Reference 03

Saccone, N.L., et al. Am. J. Med. Genet.Neuropsychiatr. Genet. 150B (4), 453-466 (2009) :

Background Reference 04

Zouridakis, M., et al. Biochim. Biophys. Acta 1794 (2) :355-366 (2009)

Other Product Names

Acetylcholine receptor subunit gamma, CHRNG, ACHRG

Tested Applications

WB

Protein ID

126302510

Physical Properties

Liquid

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