GABRE Antibody

Product Specifications

Background

The product of this gene belongs to the ligand-gated ionic channel (TC 1.A.9) family. It encodes the gamma-aminobutyric acid (GABA) A receptor which is a multisubunit chloride channel that mediates the fastest inhibitory synaptic transmission in the central nervous system. This gene encodes an epsilon subunit. It is mapped to chromosome Xq28 in a cluster comprised of genes encoding alpha 3, beta 4 and theta subunits of the same receptor. Alternatively spliced transcript variants have been identified, but only one is thought to encode a protein.

NCBI Gene ID

2564

Swiss Prot

P78334

Accession Number

P78334

Host

Rabbit

Reactivity

Human

Immunogen

This GABRE antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 66-94 amino acids from the N-terminal region of human GABRE.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Neuroscience

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

58 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

GABRE

NCBI Official Name

Gamma-aminobutyric acid receptor subunit epsilon

NCBI Organism

Homo sapiens

Background Reference 01

Pinheiro, A.P., et al. Am. J. Med. Genet.Neuropsychiatr. Genet. 153B (5), 1070-1080 (2010) :

Background Reference 02

Craddock, N., et al. Mol. Psychiatry 15 (2) :146-153 (2010)

Background Reference 03

Gratacos, M., et al. Am. J. Med. Genet.Neuropsychiatr. Genet. 150B (6), 808-816 (2009) :

Background Reference 04

Tabakoff, B., et al. BMC Biol. 7, 70 (2009) :

Other Product Names

Gamma-aminobutyric acid receptor subunit epsilon, GABA (A) receptor subunit epsilon, GABRE

Tested Applications

Protein ID

13124728

Physical Properties

Liquid

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