IQCB1 Antibody

Product Specifications

Background

This gene encodes a nephrocystin protein that interacts with calmodulin and the retinitis pigmentosa GTPase regulator protein. The encoded protein has a central coiled-coil region and two calmodulin-binding IQ domains. It is localized to the primary cilia of renal epithelial cells and connecting cilia of photoreceptor cells. The protein is thought to play a role in ciliary function. Defects in this gene result in Senior-Loken syndrome type 5. Alternative splicing results in multiple transcript variants.

NCBI Gene ID

9657

Swiss Prot

Q15051

Accession Number

Q15051

Host

Rabbit

Reactivity

Human

Immunogen

This IQCB1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 384-411 amino acids from the Central region of human IQCB1.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Neuroscience, Signal Transduction

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

69 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

IQCB1

NCBI Official Name

IQ calmodulin-binding motif-containing protein 1

NCBI Organism

Homo sapiens

Background Reference 01

Hildebrandt, F., et al. J. Am. Soc. Nephrol. 20 (1) :23-35 (2009)

Background Reference 02

Schafer, T., et al. Hum. Mol. Genet. 17 (23) :3655-3662 (2008)

Background Reference 03

Luo, X., et al. Cancer Res. 65 (23) :10725-10733 (2005)

Background Reference 04

Le Maire, A., et al. Proteins 59 (2) :347-355 (2005)

Other Product Names

IQ calmodulin-binding motif-containing protein 1, Nephrocystin-5, p53 and DNA damage-regulated IQ motif protein, PIQ, IQCB1, KIAA0036, NPHP5

Tested Applications

Protein ID

3123054

Physical Properties

Liquid

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