HAND2 Antibody

Product Specifications

Background

The protein encoded by this gene belongs to the basic helix-loop-helix family of transcription factors. This gene product is one of two closely related family members, the HAND proteins, which are asymmetrically expressed in the developing ventricular chambers and play an essential role in cardiac morphogenesis. Working in a complementary fashion, they function in the formation of the right ventricle and aortic arch arteries, implicating them as mediators of congenital heart disease. In addition, this transcription factor plays an important role in limb and branchial arch development.

NCBI Gene ID

9464

Swiss Prot

P61296

Accession Number

P61296

Host

Rabbit

Reactivity

Human

Immunogen

This HAND2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 81-110 amino acids from the Central region of human HAND2.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Neuroscience

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Homology

Predicted species reactivity based on immunogen sequence: Chicken, Mouse, Rat, Xenopus

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

24 kDa

Fragment

Rabbit Ig

Symbol

HAND2

NCBI Official Name

Heart- and neural crest derivatives-expressed protein 2

NCBI Organism

Homo sapiens

Background Reference 01

Shen, L., et al. Chin. Med. J. 123 (13) :1623-1627 (2010)

Background Reference 02

Jugessur, A., et al. PLoS ONE (7), E11493 (2010) :

Background Reference 03

Voth, H., et al. BMC Mol. Biol. 10, 28 (2009) :

Background Reference 04

Morikawa, Y., et al. Circ. Res. 103 (12) :1422-1429 (2008)

Other Product Names

Heart- and neural crest derivatives-expressed protein 2, Class A basic helix-loop-helix protein 26, bHLHa26, Deciduum, heart, autonomic nervous system and neural crest derivatives-expressed protein 2, dHAND, HAND2, BHLHA26, DHAND