RHO Antibody

Product Specifications

Background

Retinitis pigmentosa is an inherited progressive disease which is a major cause of blindness in western communities. It can be inherited as an autosomal dominant, autosomal recessive, or X-linked recessive disorder. In the autosomal dominant form, which comprises about 25% of total cases, approximately 30% of families have mutations in the gene encoding the rod photoreceptor-specific protein rhodopsin. This is the transmembrane protein which, when photoexcited, initiates the visual transduction cascade. Defects in this gene are also one of the causes of congenital stationary night blindness.

NCBI Gene ID

6010

Swiss Prot

P08100

Accession Number

P08100

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

This RHO antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 310-339 amino acids from the C-terminal region of human RHO.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Neuroscience, Signal Transduction, Growth Factors

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Homology

Predicted species reactivity based on immunogen sequence: Monkey

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

39 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

RHO

NCBI Official Name

Rhodopsin

NCBI Organism

Homo sapiens

Background Reference 01

Clark, G.R., et al. Ophthalmology 117 (11) :2169-2177 (2010)

Background Reference 02

Li, S., et al. Biochem. Biophys. Res. Commun. 401 (1) :42-47 (2010)

Background Reference 03

Pulagam, L.P., et al. J. Biol. Chem. 285 (38) :29446-29456 (2010)

Background Reference 04

Audo, I., et al. Arch. Ophthalmol. 128 (8) :1036-1045 (2010)

Other Product Names

Rhodopsin, Opsin-2, RHO, OPN2

Tested Applications

Protein ID

129207

Physical Properties

Liquid

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