GUCY2F Antibody

Product Specifications

Background

The protein encoded by this gene is a guanylyl cyclase found predominantly in photoreceptors in the retina. The encoded protein is thought to be involved in resynthesis of cGMP after light activation of the visual signal transduction cascade, allowing a return to the dark state. This protein is a single-pass type I membrane protein. Defects in this gene may be a cause of X-linked retinitis pigmentosa.

NCBI Gene ID

2986

Swiss Prot

P51841

Accession Number

P51841

Host

Rabbit

Reactivity

Human

Immunogen

This GUCY2F antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 828-856 amino acids from the C-terminal region of human GUCY2F.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Signal Transduction

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Homology

Predicted species reactivity based on immunogen sequence: Bovine, Mouse, Rat

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

125 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

GUCY2F

NCBI Official Name

Retinal guanylyl cyclase 2

NCBI Organism

Homo sapiens

Background Reference 01

Blackford, A., et al. Cancer Res. 69 (8) :3681-3688 (2009)

Background Reference 02

Helten, A., et al. J. Neurochem. 103 (4) :1439-1446 (2007)

Background Reference 03

Wood, L.D., et al. Hum. Mutat. 27 (10) :1060-1061 (2006)

Background Reference 04

Ross, M.T., et al. Nature 434 (7031) :325-337 (2005)

Other Product Names

Retinal guanylyl cyclase 2, RETGC-2, Guanylate cyclase 2F, retinal, Guanylate cyclase F, GC-F, Rod outer segment membrane guanylate cyclase 2, ROS-GC2, GUCY2F, GUC2F, RETGC2