PTP4A1 Antibody

Product Specifications

Background

The protein encoded by this gene belongs to a small class of prenylated protein tyrosine phosphatases (PTPs), which contains a PTP domain and a characteristic C-terminal prenylation motif. PTPs are cell signaling molecules that play regulatory roles in a variety of cellular processes. This tyrosine phosphatase is a nuclear protein, but may primarily associate with plasma membrane. The surface membrane association of this protein depends on its C-terminal prenylation. Overexpression of this gene in mammalian cells conferred a transformed phenotype, which implicated its role in the tumorigenesis. Studies in rat suggested that this gene may be an immediate-early gene in mitogen-stimulated cells. [provided by RefSeq].

NCBI Gene ID

7803

Swiss Prot

Q93096

Accession Number

Q93096

Host

Rabbit

Reactivity

Human, Mouse

Immunogen

This PTP4A1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 140-168 amino acids from the C-terminal region of human PTP4A1.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Signal Transduction

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Homology

Predicted species reactivity based on immunogen sequence: Monkey, Rat

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

20 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

PTP4A1

NCBI Official Name

Protein tyrosine phosphatase type IVA 1

NCBI Organism

Homo sapiens

Background Reference 01

Johnatty, S.E., et al. PLoS Genet. (7), E1001016 (2010) :

Background Reference 02

Skinner, A.L., et al. Biochemistry 48 (20) :4262-4272 (2009)

Background Reference 03

Luo, Y., et al. Biochemistry 48 (8) :1838-1846 (2009)

Background Reference 04

Min, S.H., et al. Oncogene 28 (4) :545-554 (2009)

Other Product Names

Protein tyrosine phosphatase type IVA 1, PTP (CAAXI), Protein-tyrosine phosphatase 4a1, Protein-tyrosine phosphatase of regenerating liver 1, PRL-1, PTP4A1, PRL1, PTPCAAX1