IQGAP1 Antibody

Product Specifications

Background

This gene encodes a member of the IQGAP family. The protein contains four IQ domains, one calponin homology domain, one Ras-GAP domain and one WW domain. It interacts with components of the cytoskeleton, with cell adhesion molecules, and with several signaling molecules to regulate cell morphology and motility. Expression of the protein is upregulated by gene amplification in two gastric cancer cell lines.

NCBI Gene ID

8826

Swiss Prot

P46940

Accession Number

P46940

Host

Rabbit

Reactivity

Human

Immunogen

This IQGAP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 256-285 amino acids from the N-terminal region of human IQGAP1.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cancer, Signal Transduction

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

189 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

IQGAP1

NCBI Official Name

Ras GTPase-activating-like protein IQGAP1

NCBI Organism

Homo sapiens

Background Reference 01

Hayashi, H., et al. Int. J. Cancer 126 (11) :2563-2574 (2010)

Background Reference 02

Liang, S., et al. Proteomics 10 (7) :1474-1483 (2010)

Background Reference 03

Nakhaei-Nejad, M., et al. Eur. J. Immunol. 40 (1) :204-213 (2010)

Background Reference 04

Wang, J.B., et al. J. Cell. Sci. 122 (PT 12), 2024-2033 (2009) :

Other Product Names

Ras GTPase-activating-like protein IQGAP1, p195, IQGAP1, KIAA0051

Tested Applications

Protein ID

1170586

Physical Properties

Liquid

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