PHEX Antibody

Product Specifications

Background

The protein encoded by this gene is a transmembrane endopeptidase that belongs to the type II integral membrane zinc-dependent endopeptidase family. The protein is thought to be involved in bone and dentin mineralization and renal phosphate reabsorption. Mutations in this gene cause X-linked hypophosphatemic rickets.

NCBI Gene ID

5251

Swiss Prot

P78562

Accession Number

P78562

Host

Rabbit

Reactivity

Human

Immunogen

This PHEX antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 567-595 amino acids from the C-terminal region of human PHEX.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Signal Transduction

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Homology

Predicted species reactivity based on immunogen sequence: Mouse

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

86 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

PHEX

NCBI Official Name

Phosphate-regulating neutral endopeptidase

NCBI Organism

Homo sapiens

Background Reference 01

Majewski, P.M., et al. J. Biol. Chem. 285 (45) :34828-34838 (2010)

Background Reference 02

Yokoyama, K., et al. Nephron Clin Pract 115 (4), C237-C243 (2010) :

Background Reference 03

Clausmeyer, S., et al. Calcif. Tissue Int. 85 (3) :211-220 (2009)

Background Reference 04

Gaucher, C., et al. Hum. Genet. 125 (4) :401-411 (2009)

Other Product Names

Phosphate-regulating neutral endopeptidase, 3424-, Metalloendopeptidase homolog PEX, Vitamin D-resistant hypophosphatemic rickets protein, X-linked hypophosphatemia protein, HYP, PHEX, PEX