NPRL2 Antibody

Product Specifications

Background

Suppresses Src-dependent tyrosine phosphorylation and activation of PDPK1 and its downstream signaling. Down-regulates PDPK1 kinase activity by interfering with tyrosine phosphorylation at the Tyr-9 Tyr-373 and Tyr-376 residues. May act as a tumor suppressor. Suppresses cell growth and enhanced sensitivity to various anticancer drugs.

NCBI Gene ID

10641

Swiss Prot

Q8WTW4

Accession Number

Q8WTW4

Host

Rabbit

Reactivity

Human

Immunogen

This NPRL2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 346-373 amino acids from the C-terminal region of human NPRL2.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cancer

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Homology

Predicted species reactivity based on immunogen sequence: Mouse

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

44 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

NPRL2

NCBI Official Name

Nitrogen permease regulator 2-like protein

NCBI Organism

Homo sapiens

Background Reference 01

Spielewoy, N., et al. Eukaryotic Cell 9 (4) :592-601 (2010)

Background Reference 02

Otani, S., et al.Surg Oncol 100 (5) :358-363 (2009)

Background Reference 03

Neklesa, T.K., et al. PLoS Genet. (6), E1000515 (2009) :

Background Reference 04

Anedchenko, E.A., et al. Mol. Biol. (Mosk.) 42 (6) :965-976 (2008)

Other Product Names

Nitrogen permease regulator 2-like protein, NPR2-like protein, Gene 21 protein, G21 protein, Tumor suppressor candidate 4, NPRL2, TUSC4

Tested Applications

Protein ID

47117604

Physical Properties

Liquid

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