KRT75 Antibody

Product Specifications

Background

This gene is a member of the type II keratin family clustered on the long arm of chromosome 12. Type I and type II keratins heteropolymerize to form intermediate-sized filaments in the cytoplasm of epithelial cells. This gene is expressed in the companion layer, upper germinative matrix region of the hair follicle, and medulla of the hair shaft. The encoded protein plays an essential role in hair and nail formation. Variations in this gene have been associated with the hair disorders pseudofolliculitis barbae (PFB) and loose anagen hair syndrome (LAHS) .

NCBI Gene ID

9119

Swiss Prot

O95678

Accession Number

O95678

Host

Rabbit

Reactivity

Human

Immunogen

This KRT75 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 66-92 amino acids from the N-terminal region of human KRT75.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Signal Transduction

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

60 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

KRT75

NCBI Official Name

Keratin, type II cytoskeletal 75

NCBI Organism

Homo sapiens

Background Reference 01

Sperling, L.C., et al. J. Cutan. Pathol. 37 (2) :243-248 (2010)

Background Reference 02

Liu, Z.B., et al. Tumori 95 (1) :53-62 (2009)

Background Reference 03

Nofech-Mozes, S., et al. Int. J. Surg. Pathol. 16 (4) :399-406 (2008)

Background Reference 04

Schweizer, J., et al. J. Cell Biol. 174 (2) :169-174 (2006)

Other Product Names

Keratin, type II cytoskeletal 75, Cytokeratin-75, CK-75, Keratin-6 hair follicle, hK6hf, Keratin-75, K75, Type II keratin-K6hf, Type-II keratin Kb18, KRT75, K6HF, KB18