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ATL1 Antibody

Product Specifications

Background

The protein encoded by this gene is a GTPase and a Golgi body transmembrane protein. The encoded protein can form a homotetramer and has been shown to interact with spastin and with mitogen-activated protein kinase kinase kinase kinase 4. This protein may be involved in axonal maintenance as evidenced by the fact that defects in this gene are a cause of spastic paraplegia type 3. Three transcript variants encoding two different isoforms have been found for this gene.

NCBI Gene ID

51062

Swiss Prot

Q8WXF7

Accession Number

Q8WXF7

Host

Rabbit

Reactivity

Human

Immunogen

This ATL1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 477-504 amino acids from the C-terminal region of human ATL1.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Neuroscience

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Homology

Predicted species reactivity based on immunogen sequence: Bovine, Monkey, Mouse, Rat

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Product Datasheet

https://www.prosci-inc.com/?datasheet_sku=58-730

Calculated Molecular Weight

64 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

ATL1

NCBI Official Name

Atlastin-1

NCBI Organism

Homo sapiens

Background Reference 01

Cirulli, E.T., et al. Eur. J. Hum. Genet. 18 (7) :815-820 (2010)

Background Reference 02

Park, S.H., et al. J. Clin. Invest. 120 (4) :1097-1110 (2010)

Background Reference 03

Yoshida, T., et al. Int. J. Mol. Med. 25 (4) :649-656 (2010)

Background Reference 04

De Leva, M.F., et al. J. Neurol. 257 (3) :328-331 (2010)

Other Product Names

Atlastin-1, 365-, Brain-specific GTP-binding protein, GTP-binding protein 3, GBP-3, hGBP3, Guanine nucleotide-binding protein 3, Spastic paraplegia 3 protein A, ATL1, GBP3, SPG3A

Tested Applications

WB

Protein ID

37999727

Physical Properties

Liquid

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