DNAI1 Antibody

Product Specifications

Background

The inner- and outer-arm dyneins, which bridge between the doublet microtubules in axonemes, are the force-generating proteins responsible for the sliding movement in axonemes. The intermediate and light chains, thought to form the base of the dynein arm, help mediate attachment and may also participate in regulating dynein activity. This gene encodes an intermediate chain dynein, belonging to the large family of motor proteins. Mutations in this gene result in abnormal ciliary ultrastructure and function associated with primary ciliary dyskinesia (PCD) and Kartagener syndrome.

NCBI Gene ID

27019

Swiss Prot

Q9UI46

Accession Number

Q9UI46

Host

Rabbit

Reactivity

Human

Immunogen

This DNAI1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 92-120 amino acids from the N-terminal region of human DNAI1.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Neuroscience, Signal Transduction

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Homology

Predicted species reactivity based on immunogen sequence: Bovine, Mouse, Rat

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

79 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

DNAI1

NCBI Official Name

Dynein intermediate chain 1, axonemal

NCBI Organism

Homo sapiens

Background Reference 01

Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :

Background Reference 02

Leigh, M.W., et al. Curr. Opin. Pediatr. 21 (3) :320-325 (2009)

Background Reference 03

Zuccarello, D., et al. Hum. Reprod. 23 (8) :1957-1962 (2008)

Background Reference 04

Failly, M., et al. Respiration 76 (2) :198-204 (2008)

Other Product Names

Dynein intermediate chain 1, axonemal, Axonemal dynein intermediate chain 1, DNAI1

Tested Applications

Protein ID

12643888

Physical Properties

Liquid

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